10 mai 2010

Pennington Biomedical Research Center publish new studies and findings in the area of obesity in women


"The fat mass and obesity-associated (FTO) gene was genotyped for the participants in the tiffany silver accessories-Response to Exercise in postmenopausal Women (DREW) trial and analyses were performed to determine whether an FTO variant was associated with adiposity and cardiorespiratory fitness (CRF) before and after 6 months of moderate intensity exercise in white women (n=234). The A/A homozygotes for rs8050136 had a higher BMI (kg/m[superscript]2) compared to C/C homozygotes at baseline (32.8 (0.6) vs. 31.0 (0.4), respectively; p<0.05) and at follow-up (31.9 (0.6) vs. 30.4 (0.5), respectively; p<0.05)."

"Weight loss occurred after exercise, but there was no significant genotype by exercise interaction over time. Exploratory analyses among women exposed to moderate intensity exercise meeting, or exceeding, the physical activity recommendation found that those homozygous A/A lost significantly more weight than the C allele carriers (-3.3 (0.7) kg vs. -1.4 (0.4) kg and -1.5 (0.5) kg, respectively; p<0.05). CRF, defined as VO(2peak) (oxygen consumption), increased after exercise and the tiffany silver bangles of the increase was similar for each genotype," wrote J.A. Mitchell and colleagues, Louisiana State University, Pennington Biomedical Research Center.

The researchers concluded: "Women genetically predisposed to being obese experienced weight loss and CRF benefits with moderate intensity exercise, with additional weight loss observed when the women met or exceeded the physical activity recommendations."

Mitchell and colleagues published their study in Obesity (FTO genotype and the weight loss benefits of moderate intensity exercise. Obesity, 2010;18(3):641-3).

For additional information, contact J.A. Mitchell, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana USA.

Keywords: City:Baton Rouge, State:Louisiana, Country:United States, tiffany silver bracelets, Bioengineering, Biomedical Engineering, Biomedicine, Obesity.

This article was prepared by Blood Weekly editors from staff and other reports.

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