10 mai 2010

Researchers from Pennington Biomedical Research Center provide details of new studies and findings in the area of clinical trial

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"It is difficult to identify the successful component(s) related to tiffany pendant in metabolic syndrome (MetS) from lifestyle interventions: the weight loss, the behavior change, or the combination. The purpose of this study is to determine the effects of a weight-stable randomized controlled trial of low-fat diet and exercise, alone and in combination, on MetS," researchers in the United States report.

"Men (n=179) and postmenopausal women (n=149) with elevated low-density lipoprotein cholesterol (LDL-C) and low high-density lipoprotein cholesterol (HDL-C) were randomized into a 1-year, weight-stable trial with four treatment groups: control (C), diet (D), exercise (E), or diet plus exercise (D+E). MetS was defined using a continuous score. Changes in MetS score (DeltaMetS) were compared between groups using analysis of covariance, stratified by gender and using two models, with and without baseline and change in percent body fat (DeltaBF) as a covariate. In men, DeltaMetS was higher for D vs. C (p=0.04), D+E vs. C (p=0.0002), and D+E vs. E (p=0.02). For women, DeltaMetS was greater for D vs. C (p=0.045), E vs. C (p=0.02), and D+E vs. C (p=0.004). After adjusting for DeltaBF, all differences between groups were attenuated and no longer significant. DeltaMetS were associated with tiffany pendants for both men (p <0.0001) and women (p=0.004). After adjustment for DeltaBF, low-fat diet alone and in combination with exercise had no effect on MetS," wrote S.M. Camhi and colleagues, Pennington Biomedical Research Center.

The researchers concluded: "The key component for MetS from low-fat diet and/or increased physical activity appears to be body fat loss."

Camhi and colleagues published their study in Obesity (Metabolic syndrome and changes in body fat from a low-fat diet and/or exercise randomized controlled trial. Obesity, 2010;18(3):548-54).

For additional information, contact S.M. Camhi, Population Science, Pennington Biomedical Research Center, Baton Rouge, Louisiana USA.

Keywords: City:Baton Rouge, State:Louisiana, Country:United States, Bariatrics, tiffany ring, Biomedical Engineering, Biomedicine, Clinical Trial Research, Obesity, Weight Loss.

This article was prepared by Blood Weekly editors from staff and other reports.

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